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| Registros recuperados : 59 | |
| Registros recuperados : 59 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
05/04/2021 |
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Data da última atualização: |
05/04/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
MEDEIROS, A. M. Z.; KHAN, L. U.; SILVA, G. H. da; OSPINA, C. A.; ALVES, O. L.; CASTRO, V. L. S. S. de; MARTINEZ, D. S. T. |
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Afiliação: |
ALINE MARIA ZIGIOTTO DE MEDEIROS, CNPEM; LATIF ULLAH KHAN, CNPEM; GABRIELA HELENA DA SILVA, CNPEM; CARLOS ALBERTO OSPINA, CNPEM; OSWALDO LUIZ ALVES, IQ-UNICAMP; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; DIEGO STÉFANI TEODORO MARTINEZ, CNPEM. |
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Título: |
Graphene oxide-silver nanoparticle hybrid material: an integrated nanosafety study in zebrafish embryos. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Ecotoxicology and Environmental Safety, v. 209, article 111776, 2021. |
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ISSN: |
0147-6513 |
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DOI: |
https://doi.org/10.1016/j.ecoenv.2020.111776 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: This work reports an integrated nanosafety study including the synthesis and characterization of the graphene oxide-silver nanoparticle hybrid material (GO-AgNPs) and its nano-ecotoxicity evaluation in the zebrafish embryo model. The influences of natural organic matter (NOM) and a chorion embryo membrane were considered in this study, looking towards more environmentally realistic scenarios and standardized nanotoxicity testing. The nanohybrid was successfully synthesized using the NaBH4 aqueous method, and AgNPs (~ 5.8 nm) were evenly distributed over the GO surface. GO-AgNPs showed a dose-response acute toxicity: the LC50 was 1.5 mg L-1 for chorionated embryos. The removal of chorion, however, increased this toxic effect by 50%. Furthermore, the presence of NOM mitigated mortality, and LC50 for GO-AgNPs changed respectively from 2.3 to 1.2 mg L-1 for chorionated and de-chorionated embryos. Raman spectroscopy confirmed the ingestion of GO by embryos; but without displaying acute toxicity up to 100 mg L-1, indicating that the silver drove toxicity down. Additionally, it was observed that silver nanoparticle dissolution has a minimal effect on these observed toxicity results. Finally, understanding the influence of chorion membranes and NOM is a critical step towards the standardization of testing for zebrafish embryo toxicity in safety assessments and regulatory issues. |
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Palavras-Chave: |
Alternative methods; Grafeno; Nanoecotoxicology; Nanohybrids; Nanomateriais; Nanotoxicity. |
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Thesagro: |
Composto de Carbono; Peixe de Água Doce; Toxidez. |
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Thesaurus NAL: |
chorion; Danio rerio; Ecotoxicology; Graphene oxide; Nanomaterials. |
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Categoria do assunto: |
P Recursos Naturais, Ciências Ambientais e da Terra |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/222338/1/Castro-Graphene-oxide-2021.pdf
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Marc: |
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100 1 $aMEDEIROS, A. M. Z.
245 $aGraphene oxide-silver nanoparticle hybrid material$ban integrated nanosafety study in zebrafish embryos.$h[electronic resource]
260 $c2021
520 $aAbstract: This work reports an integrated nanosafety study including the synthesis and characterization of the graphene oxide-silver nanoparticle hybrid material (GO-AgNPs) and its nano-ecotoxicity evaluation in the zebrafish embryo model. The influences of natural organic matter (NOM) and a chorion embryo membrane were considered in this study, looking towards more environmentally realistic scenarios and standardized nanotoxicity testing. The nanohybrid was successfully synthesized using the NaBH4 aqueous method, and AgNPs (~ 5.8 nm) were evenly distributed over the GO surface. GO-AgNPs showed a dose-response acute toxicity: the LC50 was 1.5 mg L-1 for chorionated embryos. The removal of chorion, however, increased this toxic effect by 50%. Furthermore, the presence of NOM mitigated mortality, and LC50 for GO-AgNPs changed respectively from 2.3 to 1.2 mg L-1 for chorionated and de-chorionated embryos. Raman spectroscopy confirmed the ingestion of GO by embryos; but without displaying acute toxicity up to 100 mg L-1, indicating that the silver drove toxicity down. Additionally, it was observed that silver nanoparticle dissolution has a minimal effect on these observed toxicity results. Finally, understanding the influence of chorion membranes and NOM is a critical step towards the standardization of testing for zebrafish embryo toxicity in safety assessments and regulatory issues.
650 $achorion
650 $aDanio rerio
650 $aEcotoxicology
650 $aGraphene oxide
650 $aNanomaterials
650 $aComposto de Carbono
650 $aPeixe de Água Doce
650 $aToxidez
653 $aAlternative methods
653 $aGrafeno
653 $aNanoecotoxicology
653 $aNanohybrids
653 $aNanomateriais
653 $aNanotoxicity
700 1 $aKHAN, L. U.
700 1 $aSILVA, G. H. da
700 1 $aOSPINA, C. A.
700 1 $aALVES, O. L.
700 1 $aCASTRO, V. L. S. S. de
700 1 $aMARTINEZ, D. S. T.
773 $tEcotoxicology and Environmental Safety$gv. 209, article 111776, 2021.
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Embrapa Meio Ambiente (CNPMA) |
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